Search results for "UDPglucose 4-Epimerase"

showing 2 items of 2 documents

Galactose increase in an infant whose mother is heterozygous for peripheral uridine diphosphate galactose‐4‐epimerase deficiency

1991

AdultGalactosemiasMaleHeterozygotemedicine.medical_specialtyUridine diphosphate galactose-4-epimeraseBiologyUDPglucose 4-Epimerasechemistry.chemical_compoundInternal medicineGeneticsmedicineHumansTransaminasesGenetics (clinical)chemistry.chemical_classificationClinical Laboratory TechniquesGalactosemiaInfant NewbornCarbohydratemedicine.diseaseBreast FeedingEndocrinologyEnzymeBiochemistrychemistryRecien nacidoGalactoseFemaleInfant FoodJournal of Inherited Metabolic Disease
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Vibrio vulnificus biotype 2 serovar E gne but not galE is essential for lipopolysaccharide biosynthesis and virulence

2008

ABSTRACT This work aimed to establish the role of gne (encoding UDP-GalNAc 4-epimerase activity) and galE (encoding UDP-Gal-4-epimerase activity) in the biosynthesis of surface polysaccharides, as well as in the virulence for eels and humans of the zoonotic serovar of Vibrio vulnificus biotype 2, serovar E. DNA sequence data revealed that gne and galE are quite homologous within this species (≥90% homology). Mutation in gne of strain CECT4999 increased the surface hydrophobicity, produced deep alterations in the outer membrane architecture, and resulted in noticeable increases in the sensitivity to microcidal peptides (MP), to eel and human sera, and to phagocytosis/opsonophagocytosis. Furt…

LipopolysaccharidesLipopolysaccharidePhagocytosisMolecular Sequence DataImmunologyMutantVirulenceVibrio vulnificusMicrobiologyMicrobiologyMiceUDPglucose 4-Epimerasechemistry.chemical_compoundBacterial ProteinsPhagocytosisVibrionaceaeAnimalsCloning MolecularVibrio vulnificusPhagocytesEelsBase SequenceVirulencebiologyChemotaxisTransferrinGene Expression Regulation Bacterialbiology.organism_classificationMolecular PathogenesisComplementationcarbohydrates (lipids)Infectious DiseaseschemistryBiofilmsMutationBacteris patògensParasitologyCarbohydrate EpimerasesBacterial outer membraneAntimicrobial Cationic Peptides
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